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Publication
Novel technique for repigmentation of senescence grey hair
Senescence grey hair equally affects women and man. To-date, the only treatment available for grey hair is application of temporary hair dye which needs to be applied frequently and often adversely effect the hair, hair follicle, and scalp. Numerous mechanisms, acting at different levels and follicular locations, contribute to hair greying, ranging from melanocyte stem cells defects to follicular melanocyte death. At the hair follicle stem cells niche, oxidative stress, accelerated by B-cell lymphoma 2 gene depletion, leads to selective apoptosis and diminution of melanocyte stem cells, reducing the repopulation of newly formed anagen follicles. A marked reduction in catalase expression and activity results in accumulation of hydrogen peroxide, contributing to bulbar melanocyte malfunction and death. Successful repigmentation of the hair is often observed in vitiligo patients. In vitiligo patients, hair follicular transplantation is one of the various surgical modalities that are performed to re-pigment skin lesions affected by vitiligo. The procedure is based on the concept of existence of undifferentiated stem cells in the hair follicle, which forms a good source of melanocytes for repigmentation.
A. Goren, Ž. Bolanča, T. Lotti, M. Šitum
FAQOther Questions
- Which diseases most commonly accompany vitiligo?
Vitiligo is rarely an isolated event. Because it involves an overactive immune system, it often coexists with other autoimmune disorders. According to extensive 10-year clinical...
- Vitiligo and hearing loss: any connection?
Vitiligo is primarily recognized for causing skin discoloration, but it can also impact melanocytes in unexpected areas, such as the inner ear. This raises questions about wheth...
- How can I cure vitiligo?
Right now, there is no universal "cure," but we have entered a new era of treatment. Today, managing vitiligo isn’t just about "hiding" it; it’s about sophisticated science that...
Though it is not always easy to treat vitiligo, there is much to be gained by clearly understanding the diagnosis, the future implications, treatment options and their outcomes.
Many people deal with vitiligo while remaining in the public eye, maintaining a positive outlook, and having a successful career.
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